Local tissue effects and peri‐implant bone healing induced by implant surface treatment: an in vivo study in the sheep

Objective: The aim of this study was to assess, through biological analysis, the local effects and osseointegration dental implants incorporating surface micro/nanofeatures compared identical design without treatment. Background: Known impact bone cell behavior, chemical topography modifications target improved long-term success implants. Very few studies assess performance presenting both micro-and nanofeatures in vivo on animal models used preclinical for medical device certification. Methods: Implant surfaces were characterized terms composition. After 4 weeks 13 implantation sheep femoral condyles, forty evaluated micro-computed tomography, histopathologic, histomorphometric analyses. Results: No adverse observed around Histomorphometric analyses showed significantly higher bone-to-implant contact coronal region treated implant at week 13, respectively 79.3$\pm$11.2% 86.4$\pm$6.7%, untreated implant's 68.3$\pm$8.8% 74.8$\pm$13%. Micro-computed tomography revealed that healing patterns differed between apical regions, with boneto-implant 13. Histopathologic results showed, undistinguishable defect margins while still presented condensation traces initial drill defect. Conclusion: Our suggest not only shows no deleterious tissues but also promotes faster implant. (word count: 241